Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

Table 6 Functional annotation of the 350 genes

Gene Ontology^a	DAVID^b
Biological process
Cell adhesion (GO:0007155)	0.0000148
Cell communication	0.000632
G-protein signaling, coupled to cyclic nucleotide second messenger	0.001940^c
System development (GO:0048731)	0.000000016
Central nervous system development	0.000293^c
Organ development (GO:0048513)	0.000017
Cellular compartment
Integral to membrane (GO:0016021)	0.0000018
Integral to plasma membrane (GO:0005887)	0.000000026
Dystrophin-associated glycoprotein complex	0.002081^c
Sarcoglycan complex	0.004398^c
Molecular function
Signal transducer activity (GO:0004871)	0.0000025
Transmembrane receptor activity (GO:0004888)	0.0000274
Transmembrane receptor protein phosphatase activity	0.003811^c
Amine receptor activity	0.004557^c
Hematopoietin/interferon-class (D200-domain) cytokine receptor activity	0.001526^c
Phosphoinositide binding	0.000737^c
GPI anchor binding	0.003257^c
Calcium-release channel activity	0.004102^c
Delayed rectifier potassium channel activity	0.001212^c
Enriched KEGG pathways	PE^b
Cell adhesion molecules (CAMs)	0.00000036
Neuroactive ligand-receptor interaction	0.000542
Allograft rejection	0.001545
Type I diabetes mellitus	0.003487

^aOnly significant Gene Ontology levels 4 or higher are indicated for clarity. ^bP-value correction: DAVID, Benjamini; Pathway Express (PE), FDR. ^cAnalysis results using GOTree Machine [32]. KEGG, Kyoto Encyclopedia of Genes and Genomes.

ISSN: 1756-994X