Skip to main content


Table 6 Functional annotation of the 350 genes

From: Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

Gene Ontologya DAVIDb
Biological process  
   Cell adhesion (GO:0007155) 0.0000148
   Cell communication 0.000632
G-protein signaling, coupled to cyclic nucleotide second messenger 0.001940c
   System development (GO:0048731) 0.000000016
Central nervous system development 0.000293c
   Organ development (GO:0048513) 0.000017
Cellular compartment  
   Integral to membrane (GO:0016021) 0.0000018
   Integral to plasma membrane (GO:0005887) 0.000000026
   Dystrophin-associated glycoprotein complex 0.002081c
Sarcoglycan complex 0.004398c
Molecular function  
   Signal transducer activity (GO:0004871) 0.0000025
   Transmembrane receptor activity (GO:0004888) 0.0000274
Transmembrane receptor protein phosphatase activity 0.003811c
Amine receptor activity 0.004557c
Hematopoietin/interferon-class (D200-domain) cytokine receptor activity 0.001526c
   Phosphoinositide binding 0.000737c
GPI anchor binding 0.003257c
   Calcium-release channel activity 0.004102c
   Delayed rectifier potassium channel activity 0.001212c
Enriched KEGG pathways PEb
   Cell adhesion molecules (CAMs) 0.00000036
   Neuroactive ligand-receptor interaction 0.000542
   Allograft rejection 0.001545
   Type I diabetes mellitus 0.003487
  1. aOnly significant Gene Ontology levels 4 or higher are indicated for clarity. bP-value correction: DAVID, Benjamini; Pathway Express (PE), FDR. cAnalysis results using GOTree Machine [32]. KEGG, Kyoto Encyclopedia of Genes and Genomes.