Figure 2

Modification of the association between IGF2BP2 and insulin sensitivity by adiposity. Genotype-specific means (± SD) were computed for IGF2BP2 rs11705701 stratified by percentage body fat tertiles in participants of the BetaGene study. The lowest body fat tertile is shown on the left and the highest body fat tertile on the right. Insulin sensitivity decreases with each copy of the T2DM risk allele within the highest body fat tertile, but decreases within the lowest body fat tertile.