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Table 2 Glioblastoma drug targets

From: Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression

Drug name

Target

Pathway

Accutane

RARA

MAPK inactivation of SMRT co-repressor

CCNU

STMN4

Signaling mediated by p38-gamma and p38-delta pathway

Celebrex

COX2

Signaling mediated by p38-alpha and p38-beta pathway

Cis-retinoic acid

RARA

MAPK inactivation of SMRT co-repressor

Sorafenib

RAF1

p38 signaling mediated by MAPKAP kinases

Tamoxifen

ESR1

Signaling mediated by p38-alpha and p38-beta pathway

  1. The table lists 6 of the 69 drugs in TCGA clinical dataset that target genes in the p38/MAPKAP pathway. MAPK, mitogen-activated protein kinase.