Figure 4From: DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinomaDNA methylation of SLC22A1 and RASSF1A in histologically normal liver tissue. (a,b) DNA methylation profiles of SLC22A1 (a) and RASSF1A (b) in normal liver tissue (n = 100, IKP-liverbank), in histologically normal tissues derived from patients with hepatocellular carcinoma (HCC; n = 20, adjacent to tumor) and in HCC tumor tissue (n = 22). DNA methylation (y-axis) at each individual CpG site (x-axis) is given. Methylation profiles show median levels (diamonds) at each CpG position (shaded areas are defined by 25%/75% quantiles). P-values are given for differences in methylation level for CpG sites between HCC (n = 22) and histologically normal liver tissue (n = 100). *P < 0.05, **P < 0.01.Back to article page