RPE-choroid genes with significantly elevated transcript levels in AMD. Box plots of age-matched normal and AMD (including pre-AMD) donor samples from the macular and extramacular RPE-choroid. All genes have a q-value ≤ 0.1 (false discovery rate ≤ 10%). Macular and extramacular P-values were calculated using a one-sided Wilcoxon rank-sum test. 'Expression' denotes net intensity, as defined in Materials and methods. Normal macula, n = 30; AMD macula, n = 35; Normal extramacula, n = 29; AMD extramacula, n = 32.