Tumors with upregulation of the CIN signature have distinctive stress phenotypes. Heat map of tumor samples as columns and Gene Ontology biological process terms as rows. Color codes are as described in Figure 2. The top part of the heat map shows the p53 mutation and estrogen receptor (ER) status in each sample. The samples with up-regulation of the CIN signature significantly upregulate genes related to important stress support mechanisms such as 'mitotic stress', 'proteotoxic stress', and so on.