The genetics of metabolic profiles in an F2 diabetic rat intercross. This linkage map (a) allows the identification of genotype-metabolite associations. The horizontal axis summarizes metabolome-wide 1H NMR spectrum variation (b). The vertical axis shows the genomic position of >2,000 microsatellite and SNP markers (c). Significant associations with a logarithm of odds (LOD) score >3 (P < 10-3) are reported and the strongest linkage signal corresponds to an association (LOD = 13) between gut microbial benzoate and a polymorphism on the UGT2b gene, responsible for its glucuronidation (d). UGT, uridine diphosphoglucuronosyltransferase. Adapted from .