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Table 4 Candidate gene studies of antidepressant treatment response undertaken in large cohorts

From: Genome-wide approaches to antidepressant treatment: working towards understanding and predicting response

Gene Study Drug Sample size Significant association
SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4) STAR*D [1] Citalopram 1,775 No (but see [2])
  GENDEP [3] Escitalopram 450 5HTTLPR, rs2020933
   Nortriptyline 345 No
  GenPod [4] Citalopram/reboxetine 520 No
HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G-protein-coupled) STAR*D [5] Citalopram 1,297 rs7997012 (also see [6])
  MARS [7] Various 451 (plus replication sample) rs7997012: reverse allelic association to [5]
  GENDEP [3] Escitalopram 422 rs931623, rs2224721
FKBP5 (FK506 binding protein 5) STAR*D [8] Citalopram 1,809 rs4713916
  MARS [9] Various 294 (plus replication sample) rs1360780, rs3800373, rs4713916
  GENDEP [3] Escitalopram or nortriptyline 733 No
GRIK4 (glutamate receptor, ionotropic, kainate 4) STAR*D [6] Citalopram 1,816 rs1954787
  MARS [10] Various 300 No