From: Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles
Common MeSH term | Gene MeSHOP P-value | Disease MeSHOP P-value | Score |
---|---|---|---|
DNA mutational analysis | 0.00E+00 | 0.00E+00 | 0.00e+0 |
Pedigree | 0.00E+00 | 0.00E+00 | 0.00e+0 |
Polymorphism, single-stranded conformational | 1.40E-44 | 1.67E-42 | 1.66e-42 |
Humans | 6.82E-24 | 0.00E+00 | 6.82e-24 |
Exons | 8.53E-24 | 2.98E-23 | 2.13e-23 |
Mutation, missense | 1.45E-23 | 9.72E-21 | 9.70e-21 |
Chromosomes, human, pair 11 | 2.73E-20 | 0.00E+00 | 2.73e-20 |
Codon, nonsense | 1.15E-18 | 1.96E-21 | 1.15e-18 |
Cataract | 2.37E-17 | 0.00E+00 | 2.37e-17 |
Point mutation | 6.94E-17 | 7.02E-18 | 6.24e-17 |
Frameshift mutation | 9.77E-15 | 2.11E-21 | 9.77e-15 |
DNA primers | 5.27E-12 | 2.69E-15 | 5.27e-12 |
Fovea centralis | 2.41E-16 | 6.03E-11 | 6.03e-11 |
Introns | 5.01E-10 | 2.15E-13 | 5.01e-10 |
Nystagmus, congenital | 9.55E-10 | 3.29E-11 | 9.22e-10 |
Genes, dominant | 7.39E-09 | 2.45E-14 | 7.39e-9 |
Asian continental ancestry group | 2.23E-16 | 1.07E-08 | 1.07e-8 |
Lens, crystalline | 2.40E-08 | 5.62E-24 | 2.40e-8 |
Alternative splicing | 6.14E-13 | 7.97E-08 | 7.97e-8 |
Corneal opacity | 2.45E-06 | 1.47E-16 | 2.45e-6 |
Child, preschool | 3.63E-06 | 3.08E-44 | 3.63e-6 |
Family health | 1.03E-05 | 1.69E-07 | 1.01e-5 |
Gene expression regulation, developmental | 2.46E-15 | 1.04E-05 | 1.04e-5 |
Genes, homeobox | 1.40E-05 | 6.32E-09 | 1.40e-5 |
Adolescent | 1.92E-05 | 1.71E-18 | 1.92e-5 |
Conserved sequence | 6.20E-06 | 1.18E-04 | 1.12e-4 |
Heterozygote | 1.15E-04 | 6.94E-08 | 1.15e-4 |
Radiation hybrid mapping | 1.72E-05 | 1.50E-04 | 1.33e-4 |
Alleles | 2.29E-04 | 4.17E-05 | 1.87e-4 |
Abnormalities, multiple | 2.91E-04 | 0.00E+00 | 2.91e-4 |
Iris | 3.45E-04 | 0.00E+00 | 3.45e-4 |
Blepharoptosis | 4.54E-04 | 4.55E-08 | 4.53e-4 |
WAGR syndrome | 5.13E-04 | 0.00E+00 | 5.13e-4 |
Tomography, optical coherence | 1.14E-03 | 4.47E-04 | 6.97e-4 |
Corpus callosum | 6.03E-07 | 9.38E-04 | 9.38e-4 |
Pregnancy | 9.62E-01 | 9.60E-01 | 1.09e-3 |
Open reading frames | 2.56E-10 | 1.12E-03 | 1.12e-3 |
Forkhead transcription factors | 1.27E-03 | 1.95E-05 | 1.25e-3 |
Face | 1.42E-03 | 3.94E-05 | 1.38e-3 |
Nucleic acid heteroduplexes | 2.02E-04 | 1.73E-03 | 1.53e-3 |
In situ hybridization, fluorescence | 1.61E-03 | 3.22E-29 | 1.61e-3 |
Gene deletion | 1.65E-03 | 1.77E-21 | 1.65e-3 |
PAX9 transcription factor | 8.46E-04 | 2.50E-03 | 1.66e-3 |
Proprotein convertase 1 | 1.71E-03 | 1.27E-05 | 1.69e-3 |
Ectopia lentis | 1.81E-03 | 1.42E-05 | 1.79e-3 |
Albinism, ocular | 1.86E-03 | 3.98E-14 | 1.86e-3 |
Databases, nucleic acid | 3.09E-04 | 2.63E-03 | 2.32e-3 |
India | 1.13E-04 | 2.79E-03 | 2.68e-3 |
Amino acid substitution | 2.03E-06 | 3.07E-03 | 3.06e-3 |
Transcriptional activation | 1.10E-23 | 3.22E-03 | 3.22e-3 |
Genetic markers | 3.43E-03 | 1.71E-10 | 3.43e-3 |
Anophthalmos | 5.77E-03 | 1.45E-04 | 5.63e-3 |
3' Untranslated regions | 8.26E-06 | 5.66E-03 | 5.65e-3 |
Young adult | 1.18E-02 | 4.91E-03 | 6.84e-3 |
Limbus corneae | 7.58E-03 | 1.48E-18 | 7.58e-3 |
RNA, transfer, Lys | 4.19E-03 | 1.23E-02 | 8.16e-3 |
Dna transposable elements | 9.49E-03 | 9.94E-04 | 8.50e-3 |
Heteroduplex analysis | 4.54E-03 | 1.34E-02 | 8.84e-3 |
Chromosome deletion | 9.12E-03 | 0.00E+00 | 9.12e-3 |
Homozygote | 1.09E-02 | 1.29E-03 | 9.57e-3 |
Otx transcription factors | 5.70E-06 | 1.00E-02 | 9.99e-3 |
Genetic predisposition to disease | 1.16E-02 | 8.84E-05 | 1.15e-2 |
Microphthalmos | 1.17E-02 | 2.34E-12 | 1.17e-2 |
Vision, low | 1.24E-02 | 6.65E-04 | 1.17e-2 |
Optic nerve | 1.26E-02 | 5.64E-08 | 1.26e-2 |
Exotropia | 7.21E-03 | 2.12E-02 | 1.40e-2 |
Cytosine | 2.70E-03 | 2.15E-02 | 1.88e-2 |
Magnetic resonance imaging | 4.92E-04 | 1.96E-02 | 1.92e-2 |
United States | 9.81E-01 | 1.00E+00 | 1.93e-2 |
Trabecular meshwork | 2.22E-02 | 2.11E-03 | 2.01e-2 |
Polymorphism, restriction fragment length | 2.30E-02 | 7.12E-04 | 2.23e-2 |
Body patterning | 3.32E-03 | 2.62E-02 | 2.29e-2 |
Dichotic listening tests | 1.21E-02 | 3.55E-02 | 2.34e-2 |
Multigene family | 2.46E-02 | 8.37E-04 | 2.38e-2 |
3T3 Cells | 3.00E-06 | 2.67E-02 | 2.67e-2 |
Cognition disorders | 4.77E-02 | 2.05E-02 | 2.72e-2 |
Esotropia | 1.42E-02 | 4.14E-02 | 2.72e-2 |
Mutagenesis, insertional | 4.08E-03 | 3.18E-02 | 2.77e-2 |
Endothelium, corneal | 2.94E-02 | 1.06E-04 | 2.93e-2 |
Restriction mapping | 3.25E-02 | 2.53E-06 | 3.25e-2 |
Thymine | 4.15E-02 | 7.24E-03 | 3.43e-2 |
Sequence homology, amino acid | 3.52E-02 | 3.31E-04 | 3.49e-2 |
Glutamine | 5.38E-03 | 4.13E-02 | 3.59e-2 |
Chromosomes, human, pair 10 | 1.97E-02 | 5.72E-02 | 3.75e-2 |
Cytogenetics | 3.86E-02 | 2.41E-04 | 3.84e-2 |
Nervous system malformations | 5.11E-02 | 9.30E-02 | 4.18e-2 |
Organ specificity | 2.36E-01 | 1.90E-01 | 4.62e-2 |
Catenins | 6.22E-02 | 1.59E-02 | 4.63e-2 |
Genetic heterogeneity | 2.45E-02 | 7.09E-02 | 4.64e-2 |
Brain-derived neurotrophic factor | 5.07E-02 | 6.24E-07 | 5.07e-2 |
Chromosomes, human, pair 12 | 2.70E-02 | 7.77E-02 | 5.08e-2 |
Leucine zippers | 1.64E-04 | 5.28E-02 | 5.26e-2 |
Verbal behavior | 2.09E-01 | 1.53E-01 | 5.57e-2 |
Mice, transgenic | 6.20E-02 | 5.89E-03 | 5.61e-2 |
Visual acuity | 5.65E-02 | 0.00E+00 | 5.65e-2 |
DNA fingerprinting | 9.30E-02 | 3.44E-02 | 5.85e-2 |
Sequence alignment | 1.69E-02 | 7.59E-02 | 5.90e-2 |
Autistic disorder | 9.48E-02 | 3.57E-02 | 5.91e-2 |
Fluorescent antibody technique, indirect | 9.84E-02 | 3.83E-02 | 6.00e-2 |
Age factors | 9.37E-01 | 9.97E-01 | 6.03e-2 |