Skip to main content

Table 8 Top 50 Alzheimer disease candidate genes by MeSHOP similarity

From: Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles

Rank Gene ID Gene name Score Génie rank Alzheimer disease gene2pubmedreferences
1 348 APOE 1.18E+04 4 812
2 351 APP 1.22E+04 2 576
3 4137 MAPT 1.23E+04 1 211
4 5663 PSEN1 1.27E+04 3 249
5 6622 SNCA 1.27E+04 6 30
6 627 BDNF 1.28E+04 9 47
7 1312 COMT 1.29E+04 87 10
8 1401 CRP 1.29E+04 210 5
9 6532 SLC6A4 1.30E+04 43 23
10 3064 HTT 1.30E+04 44 0
11 5444 PON1 1.30E+04 204 16
12 1813 DRD2 1.30E+04 114 1
13 4846 NOS3 1.30E+04 118 18
14 23621 BACE1 1.30E+04 5 86
15 2950 GSTP1 1.30E+04 470 4
16 5621 PRNP 1.31E+04 12 28
17 5054 SERPINE1 1.31E+04 NA 3
18 1636 ACE 1.31E+04 32 45
19 2952 GSTT1 1.31E+04 NA 3
20 5071 PARK2 1.31E+04 13 6
21 120892 LRRK2 1.31E+04 18 6
22 3553 IL1B 1.31E+04 39 32
23 4023 LPL 1.31E+04 172 7
24 6647 SOD1 1.31E+04 36 6
25 3356 HTR2A 1.31E+04 121 16
26 10 NAT2 1.31E+04 333 4
27 7515 XRCC1 1.31E+04 NA 2
28 2944 GSTM1 1.31E+04 NA 3
29 3552 IL1A 1.31E+04 30 36
30 3569 IL6 1.32E+04 60 28
31 5664 PSEN2 1.32E+04 7 78
32 6648 SOD2 1.32E+04 131 4
33 2153 F5 1.32E+04 NA 0
34 338 APOB 1.32E+04 NA 1
35 7421 VDR 1.32E+04 NA 2
36 2147 F2 1.32E+04 NA 0
37 183 AGT 1.32E+04 NA 2
38 1543 CYP1A1 1.32E+04 NA 1
39 154 ADRB2 1.32E+04 NA 1
40 4524 MTHFR 1.32E+04 57 30
41 1071 CETP 1.32E+04 197 8
42 3557 IL1RN 1.32E+04 278 7
43 4318 MMP9 1.32E+04 219 5
44 1565 CYP2D6 1.32E+04 238 9
45 335 APOA1 1.32E+04 135 7
46 7517 XRCC3 1.32E+04 NA 0
47 3990 LIPC 1.32E+04 NA 2
48 4153 MBL2 1.32E+04 NA 1
49 23435 TARDBP 1.32E+04 10 10
50 345 APOC3 1.32E+04 NA 2
  1. Genes are ranked by MeSHOP similarity score, and compared against the ranked list of Génie candidate genes for Alzheimer disease (a full analysis considering all possible orthologs). Also provided is a list of the number of articles related to Alzheimer disease in the gene2pubmed references for the gene, when present. Rows in bold indicate high-ranking predictions that have no prior association with Alzheimer disease in the literature. NA: gene not among the 566 genes ranked by Génie.