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Table 8 Top 50 Alzheimer disease candidate genes by MeSHOP similarity

From: Inferring novel gene-disease associations using Medical Subject Heading Over-representation Profiles

Rank

Gene ID

Gene name

Score

Génie rank

Alzheimer disease gene2pubmedreferences

1

348

APOE

1.18E+04

4

812

2

351

APP

1.22E+04

2

576

3

4137

MAPT

1.23E+04

1

211

4

5663

PSEN1

1.27E+04

3

249

5

6622

SNCA

1.27E+04

6

30

6

627

BDNF

1.28E+04

9

47

7

1312

COMT

1.29E+04

87

10

8

1401

CRP

1.29E+04

210

5

9

6532

SLC6A4

1.30E+04

43

23

10

3064

HTT

1.30E+04

44

0

11

5444

PON1

1.30E+04

204

16

12

1813

DRD2

1.30E+04

114

1

13

4846

NOS3

1.30E+04

118

18

14

23621

BACE1

1.30E+04

5

86

15

2950

GSTP1

1.30E+04

470

4

16

5621

PRNP

1.31E+04

12

28

17

5054

SERPINE1

1.31E+04

NA

3

18

1636

ACE

1.31E+04

32

45

19

2952

GSTT1

1.31E+04

NA

3

20

5071

PARK2

1.31E+04

13

6

21

120892

LRRK2

1.31E+04

18

6

22

3553

IL1B

1.31E+04

39

32

23

4023

LPL

1.31E+04

172

7

24

6647

SOD1

1.31E+04

36

6

25

3356

HTR2A

1.31E+04

121

16

26

10

NAT2

1.31E+04

333

4

27

7515

XRCC1

1.31E+04

NA

2

28

2944

GSTM1

1.31E+04

NA

3

29

3552

IL1A

1.31E+04

30

36

30

3569

IL6

1.32E+04

60

28

31

5664

PSEN2

1.32E+04

7

78

32

6648

SOD2

1.32E+04

131

4

33

2153

F5

1.32E+04

NA

0

34

338

APOB

1.32E+04

NA

1

35

7421

VDR

1.32E+04

NA

2

36

2147

F2

1.32E+04

NA

0

37

183

AGT

1.32E+04

NA

2

38

1543

CYP1A1

1.32E+04

NA

1

39

154

ADRB2

1.32E+04

NA

1

40

4524

MTHFR

1.32E+04

57

30

41

1071

CETP

1.32E+04

197

8

42

3557

IL1RN

1.32E+04

278

7

43

4318

MMP9

1.32E+04

219

5

44

1565

CYP2D6

1.32E+04

238

9

45

335

APOA1

1.32E+04

135

7

46

7517

XRCC3

1.32E+04

NA

0

47

3990

LIPC

1.32E+04

NA

2

48

4153

MBL2

1.32E+04

NA

1

49

23435

TARDBP

1.32E+04

10

10

50

345

APOC3

1.32E+04

NA

2

  1. Genes are ranked by MeSHOP similarity score, and compared against the ranked list of Génie candidate genes for Alzheimer disease (a full analysis considering all possible orthologs). Also provided is a list of the number of articles related to Alzheimer disease in the gene2pubmed references for the gene, when present. Rows in bold indicate high-ranking predictions that have no prior association with Alzheimer disease in the literature. NA: gene not among the 566 genes ranked by Génie.