Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival

Table 3 Representative KEGG pathways from signaling pathway impact analysis of gene expression differences between GNS and NS cell lines

Pathway	Genes	P	Predicted status in GNS cells
Cytokine-cytokine receptor interaction	29	4.4 × 10^-12	Activated
Chemokine signaling pathway	15	5.3 × 10^-6	Activated
Neuroactive ligand-receptor interaction	21	2.2 × 10^-4	Inhibited
Antigen processing and presentation	11	6.8 × 10^-4	Activated
MAPK signaling pathway	24	0.0106	Activated
Glioma	10	0.0131	Activated
ECM-receptor interaction	10	0.0405	Inhibited
Calcium signaling pathway	15	0.0405	Activated

The number of genes found to be differentially expressed at 10% FDR and belonging to the selected pathways are indicated. P-values and status predictions were obtained by signaling pathway impact analysis [26], taking fold-change estimates and pathway topology into account. P-values were FDR-corrected for multiple testing. ECM, extracellular matrix; MAPK, mitogen-activated protein kinase.

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