Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival

Table 4 Novel candidate glioma genes identified by differential expression and pathway analysis

Gene^a	Log₂ fold-change^b	Prior association with glioma	Implication in other neoplasms	Reference
CACNA1A	7.1	None	Prostate cancer (mouse model)	[80]
CACNA1C	-8.2	None	Liver cancer	[81]
CACNG7	-2.6	None	None	--
CACNG8	-4.8	None	None	--
CAMK1D	-2.4	None	Breast cancer	[82]
CPLX2	6.4	None	None	--
DDIT3 (CHOP, GADD153)	4.4	Limited	General (cellular stress response)	[83–86]
DUSP16	4.2	None	Burkitt's lymphoma	[87]
FGF19	-	None	Liver, lung and colon cancer	[88]
ITGA4 (CD49D)	3.0	Limited	Chronic lymphocytic leukemia, breast cancer and others	[89–91]
ITGBL1	+	None	None	--
MAP3K5 (ASK1)	5.1	Limited	Gastric cancer and histiocytoma	[92–94]
NFATC2 (NFAT1)	+	Limited	Breast cancer	[95–98]
NFKBIZ	5.1	None	Liposarcoma	[99]
NR0B1 (DAX1)	+	None	Lung adenocarcinoma and Ewing's sarcoma	[100, 101]
NR1D1	2.9	None	Breast cancer	[102]
PARP3, PARP12	4.1, 2.9	By homology^c	The PARP gene family is involved in DNA repair and several other processes related to tumorigenesis	[103, 104]
PERP	3.8	None	Lung and skin cancer	[105, 106]
PPEF1	4.4	Limited	None	[107]
SNAP25	3.3	None	Lung cancer	[108]
SYT1	-2.5	None	None	--
TNFRSF14	4.0	None	Follicular lymphoma	[109]
TNFSF4 (OX40L)	4.0	None	Generally implicated in immune response to tumors	[110]

^aAliases are listed in parentheses. ^bGene expression log₂ fold-change between GNS and NS cell lines compared by Tag-seq. Some genes were detected exclusively in GNS or NS cells (indicated in column 2 by + or -, respectively). ^cThe homolog PARP1 has been implicated in glioma. PARP, poly(ADP-ribose) polymerase.

ISSN: 1756-994X