Figure 2

Sub-stage analysis for three-gene biomarker and power analysis. (a-d) The performance of the three-gene biomarker was evaluated in a sub-stage analysis (stage IA (a), stage IB (b), stage II (c) and stage III (d) patients). Each patient was classified into good (blue curves) and poor (red curves) prognosis groups using the three-gene biomarker and were displayed with Kaplan-Meier curves. Hazard ratios and P-values are from Cox proportional hazard ratio modeling followed by the Wald test. (e) Subsequently, power calculations (assuming equal-sized groups) were performed at a range of HRs for all patients and for patients of specific stages. A threshold line is drawn for power of 0.8.