Figure 3
From: Genes and epigenetic processes as prospective pain targets
How epigenetic mechanisms can influence pain processing. (a) Under normal conditions, histone tails are acetylated at the GAD2 promoter in the nucleus raphe magnus (NRM). (b) After application of complete Freund's adjuvant (CFA), Gad65 expression is suppressed through hypoacetylation of the GAD2 promoter, leading to loss of descending inhibition from the NRM [84]. GABA, γ-aminobutyric acid.