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Table 4 Examples of proteomic studies of osteoporosisa

From: Genome-wide approaches for identifying genetic risk factors for osteoporosis

Participants or cells/treatment Identified protein expression Related functions/pathways Refs
Human bone MSCs 64 secreted proteins upregulated, especially SMOC1 Osteoblast mineralization [82]
Human PBMs ANXA2 Osteoclast differentiation [39]
Human osteocytes LRP4 A sclerostin interaction partner [87]
Chinese with low BMD SOD 2 upregulated Located in circulating monocytes (potential osteoclast precursors) [89]
Osteoblast differentiation in mouse osteoprogenitor MC3T3-E1 cells Upregulation of IQGAP1, gelsolin, moesin, radixin, and CFL1 Cytoskeleton regulation [79]
  Upregulation of FLNA, LAMA1, LAMA5, COL1A1, COL3A1, COL4A6, COL5A2; downregulation of COL4A1, COL4A2, and COL4A4 Focal adhesion signaling [79]
Osteoblast differentiation in MC3T3-E1 preosteoblast cells/ leukocyte common antigen-related tyrosine phosphatase ALP, BSP, DLX5, OCN, and RUNX2 Erk activation [80]
Osteoblasts and osteoclasts induced from RAW 264.7 macrophage cell line (from murine blood)/Er-Xian Decoction treatment In osteoblasts: 8 proteins upregulated Hmgb1, acidic ribosomal phosphoprotein P0, histone H2, carbonyl reductase 1, ATP synthase, aldolase A, and GDIα [78]
  In osteoblasts: 3 proteins downregulated Carbonic anhydrase 3, prohibitin, hemiferrin, far upstream element-binding protein [78]
  In osteoclasts: 3 proteins upregulated Vimentin, protein disulfide isomerase associated 3 and α-fetoprotein [78]
  In osteoclasts: 1 protein downregulated Calnexin [78]
Rat primary calvarial osteoblast/Kaempferol 9 proteins upregulated, 9 downregulated Including cytoskeletal proteins, intracellular signaling protein, chaperone, extracellular matrix protein, and proteins involved in glycolysis and cell-matrix interactions [77]
Ovariectomized rats SOD1, ATP synthase, and COMT Protection against bone loss [90]
  1. aFor gene abbreviations and explanations of pathways, see Table 5.