Table 3 Low-frequency recurrently mutated genes in CLL
From: Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics
| Gene | Frequency (%) | Likely gene function |
|---|---|---|
| XPO1 | 2 to 4 [33, 75] | Nuclear export |
| CHD2 | 4 to 5 [40, 75] | Chromatin modification |
| POT1 | 3 to 5 [40, 75] | Telomere maintenance |
| HIST1H1E | 3 [75] | Histone protein |
| NRAS | 3 [75] | Cell growth |
| BCOR | 3 [75] | Apoptosis regulation |
| ZMYM3 | 3 [34, 75] | Chromatin modification |
| RIPK1 | 3 [75] | Inflammatory pathway |
| SAMHD1 | 3 [75] | Innate immune response |
| KRAS | 2 [75] | Cell growth |
| MED12 | 2 [75] | Gene transcription |
| ITPKB | 2 [75] | B-cell signaling |
| DDX3X | 2 [34, 75] | RNA helicase |
| EGR2 | 1 [75] | Transcription factor |
| FBXW7 | 3 [34, 75] | Ubiquitination |
| KLHL6 | 2 [33] | B-cell receptor signaling |
| MAPK1 | 3 [34] | MAP kinase |
| LRP1B | 5 [40] | LDL receptor family |