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Table 3 Low-frequency recurrently mutated genes in CLL

From: Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics

Gene Frequency (%) Likely gene function
XPO1 2 to 4 [33, 75] Nuclear export
CHD2 4 to 5 [40, 75] Chromatin modification
POT1 3 to 5 [40, 75] Telomere maintenance
HIST1H1E 3 [75] Histone protein
NRAS 3 [75] Cell growth
BCOR 3 [75] Apoptosis regulation
ZMYM3 3 [34, 75] Chromatin modification
RIPK1 3 [75] Inflammatory pathway
SAMHD1 3 [75] Innate immune response
KRAS 2 [75] Cell growth
MED12 2 [75] Gene transcription
ITPKB 2 [75] B-cell signaling
DDX3X 2 [34, 75] RNA helicase
EGR2 1 [75] Transcription factor
FBXW7 3 [34, 75] Ubiquitination
KLHL6 2 [33] B-cell receptor signaling
MAPK1 3 [34] MAP kinase
LRP1B 5 [40] LDL receptor family