Figure 3
From: Whole genome sequencing in support of wellness and health maintenance
Joint representation of clinical and genetic risk assessment. (A) Metabolic risk showing joint genotypic likelihood ratios for obesity (OB), Type 2 diabetes (T2D), and hypertriglyceridemia (HTG) as bars, and related clinical measures as the indicated points, for each of the 8 individuals in the study. (B) Similar cardiovascular risk assessments for hypertension (HTN), myocardial infarction (MI), and coronary artery disease (CAD) as bars, along with related clinical measures and/or Framingham Risk Score. All measures were averaged over the first three visits to the Center for Health Discovery and Well Being (CHDWB). (C) Proposal for 'gridiron plot' representation of clinical risk (y-axis) against genotypic risk (z-axis) in eight disease domains described in the text, for individual CHD-5. The plot gives a glimpse of where the two types of assessment are concordant (for example, cardiovascular disease (CVD), cardiovascular)or discordant (that is, immunological (IMM)), and more refined analyses such as in (A) and (B) provide further clues as to the genetic basis of overall risk.