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Figure 1 | Genome Medicine

Figure 1

From: Pathprinting: An integrative approach to understand the functional basis of disease

Figure 1

The Pathprint pipeline. Rank-normalized gene expression is mapped to pathway expression. A distribution of expression scores across the Gene Expression Omnibus (GEO is used to produce a probability of expression (POE) for each pathway. A pathprint vector is derived by transformation of the signed POE distribution into a ternary score, representing pathway activity as significantly underexpressed (-1), intermediately expressed (0), or overexpressed (+1).

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