Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease

Table 1 The frequencies of estimated 6-SNP haplotypes^† for the 9p21.3 T2D locus in seven different geographic regions

rs2383208	rs7045889	rs10811659	rs10757282	rs10811661	rs10757283	Africa N = 102	Middle East N = 160	Europe N = 156	C.S. Asia N = 200	E. Asia N = 229	Oceania N = 28	America N = 63
G	A	A	G	C	T	0.029	0.197	0.157	0.125	0.393	0.446	0.167
A	A	A	G	T*	T*	0.118	0.187	0.266	0.221	0.215	0.196	0.206
G	G	A	A	T*	T*	0.131	0.022	NF	NF	NF	NF	NF
A	A	A	A	T*	T*	0.182	NF	NF	NF	NF	NF	NF
G	A	A	A	T*	T*	0.052	NF	NF	NF	NF	NF	NF
A	G	A	A	T	C	0.302	0.334	0.308	0.418	0.244	0.089	0.547
A	A	G	A	T	C	0.022	0.177	0.198	0.199	0.091	0.161	NF
A	G	G	A	T	C	0.051	0.038	0.046	0.018	0.011	0.071	0.024
G	G	A	A	T	C	0.042	0.015	NF	NF	NF	NF	NF
A	A	A	A	T	C	0.053	NF	NF	NF	NF	NF	0.024

The TT haplotype of SNPs rs10811661 and rs10757283 is the T2D risk haplotype and is in bold-face and marked with an asterisk, while the protective haplotype (GAAGCT) is in bold-face and italicized. ^†Population-specific haplotypes <5% frequent were omitted. NF, haplotype not found in given geographic region.

ISSN: 1756-994X