Figure 6
From: STAG2 is a clinically relevant tumor suppressor in pancreatic ductal adenocarcinoma
Synthetic lethal analysis of STAG2 knockdown and exposure to chemotherapeutic agents in PDA cells. (A) Synthetic lethal response of PANC-1 cells and (B) Panc 04.03 cells in the presence of oxaliplatin. (C) Absence of response of PANC-1 cells in the presence of gemcitabine. Asterisks indicate that all four siRNA sequences at drug concentrations of 3.7 and 11.1 μM have P < 0.01 when compared to GFP control. Error bars in (A-C) represent standard deviations. (D) Western blot of STAG2 expression in PANC1 cells in the presence of control (GFP) and four STAG2 siRNAs. (E) Drugs used in siRNA synthetic lethal screen.