Figure 2
Replicated association of axes of variation with myocardial infarction. Each gene that is correlated with one of the nine axes in both phases is plotted, showing the mean difference between individuals with and without AMI (higher expression in AMI producing negative values). The overall relationship of the axes with AMI status is highly replicated, notably showing downregulation of axis 1 and upregulation of axis 5. The difference between the studies in axis 2 is readily explained because this axis is associated with BMI, which is elevated in the replication phase sample.