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Table 2 Genetic and functional effect of mutations in oncogenes and tumor suppressors

From: DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes

   Functional effect
   Gain Loss
Genetic effect Dominant Typical OG Dominant negative TSG
Recessive None Typical TSG
  1. A driver cancer gene is defined by a genetic effect (dominant, recessive) and a functional effect (gain or loss). These two components ultimately define the tumor suppressor and oncogene characteristics that we try to infer from the mutational landscape (structural effect).