From: DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes
 |  | Structural landscape | |||
---|---|---|---|---|---|
 | Missense | Clustered | No | Clustered | Any |
 | Truncating | No | Diffuse | Diffuse | Clustered |
Biological classification | Oncogene | Typical (gain-of-function) for example, KRAS | None found | None found | Atypical (gain of function through loss of inhibition) for example, NPM1 |
Tumor suppressor | Atypical (dominant negative, gain-of-function) | Typical (loss-of-function) | Atypical (possible dominant negative, gain-of-function*) | None found | |
for example, SMARCA4 in lymphoma | for example, RB1 | for example, TP53 in UCEC or DNMT3A in AML |