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Table 3 Characteristics of the samples used from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

From: A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival

Hormones Breast cancer (#Samples) Methylation signature P value
   Positive (SD) Negative (SD)  
Mean oestradiol, pg/mL Yes (65) 20.51 (16.74) 18.67 (10.09) 0.59
  No (115) 17.36 (8.32) 19.24 (8.11) 0.22
Mean free oestradiol, pmol/L Yes (65) 0.98 (0.58) 0.99 (0.55) 0.95
  No (114) 0.84 (0.43) 1.02 (0.59) 0.05
Mean oestrone, pg/mL Yes (67) 126.7 (156.59) 97.22 (58.10) 0.31
  No (117) 112.7 (91.86) 97.55 (92.41) 0.38
Mean androstendione, nmol/L Yes (64) 3.35 (1.66) 3.96 (2.00) 0.19
  No (118) 3.4 (2.10) 3.13 (1.41) 0.41
Mean testosterone, nmol/L Yes (65) 0.30 (0.17) 0.35 (0.20) 0.3
  No (115) 0.28 (0.17) 0.31 (0.19) 0.42
Mean free testosterone, ng/dl Yes (65) 0.12 (0.08) 0.14 (0.10) 0.35
  No (115) 0.11 (0.07) 0.13 (0.09) 0.17
Mean SHBG, nmol/L Yes (66) 57.54 (37.71) 49.79 (19.86) 0.24
  No (116) 61.26 (26.46) 54.49 (24.36) 0.16
Mean progesterone, ng/mL Yes (66) 0.63 (2.13) 0.28 (0.21) 0.34
  No (114) 0.27 (0.17) 0.28 (0.16) 0.84
Mean DHEAS, ug/dl Yes (66) 109.6 (57.54) 92.52 (56.75) 0.23
  No (116) 115.8 (65.49) 107.1 (57.92) 0.45
Mean ER alpha, pg/mL Yes (67) 89.67 (87.33) 81.23 (56.48) 0.64
  No (120) 69.54 (62.56) 75.29 (61.84) 0.61
Mean ER beta, pg/mL Yes (67) 87.06 (122.37) 64.01 (75.85) 0.35
  No (120) 56.74 (62.83) 60.95 (72.14) 0.73
Mean AR, ng/mL Yes (67) 2.5 (0.95) 2.4 (0.91) 0.78
  No (119) 2.28 (1.11) 2.45 (0.96) 0.37
  1. The samples were categorised according to their individual risk scores. These risk scores are the product of the methylation profile with the regression coefficients of the signature. The statistical significance was assessed by a t-test. The missing values were excluded from the analysis.
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Genome Medicine

ISSN: 1756-994X

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