Table 1 Epigenetic alterations of enhancers found in malignancies

Colon

Gains and losses of H3K4me1

[81]

Breast, cervical, colon, pancreatic, prostate, blood

Gains and losses of super-enhancers

[28],[82],[83]

Breast, lung, cervical

Gains and losses of DNA methylation

[79]

Melanoma, breast, T-cell leukemia

Gains and losses of open chromatin (DNase)

[26]

Breast

Gains and losses of H3K4me2, open chromatin

[84]

T-cell acute lymphoblastic leukemia

Global chromatin compaction, reduced H3K27ac

[85]

Breast, colon, laryngeal squamous cell

HOTAIR overexpression, gains of H3K27me3

[86]-[88]

Hepatocellular

HOTTIP overexpression, increased HOXA13 overexpression

[89]

Colon

CCAT1-L overexpression, chromatin looping to MYC

[90],[91]