A HIF-1-dependent subnetwork is specifically dysregulated in APL. (A) A subnetwork was obtained by extracting from the overall AML network only transcripts that are differentially expressed (FDR adjusted P-value <0.05) in the comparison between APL (M3) and other AML subtypes in two AML data sets. Six HIF-1 direct targets are included: MMP2, KRT18 and IGFBP2 in the up-regulated module; and ITGB2, HMOX1 and LRP1 in the vast community that is mostly down-regulated and centered on them. (B) The same subnetwork observed across different AML subtypes (from M0 to M5). Down-regulated transcripts are in blue, up-regulated transcripts are in red, non-differentially expressed transcripts are empty circles.