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Figure 4 | Genome Medicine

Figure 4

From: Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

Figure 4

RNA sequencing analysis of gene expression in seven peripheral blood leukocyte populations and four T-helper cell populations from cord blood. The heat maps show the expression of all genes located in AID loci: (A) lncRNAs; (B) protein-coding genes and AID genes shared by at least two diseases: (C) lncRNAs; (D) protein-coding genes. Unsupervised hierarchical clustering analysis of gene expression profiles of all 11 cell types (granulocytes, monocytes, NK cells, B cells, memory T cells (both CD4+ and CD8+), naive CD4+and naive CD8+ T cells (cytotoxic T cells), precursor T-helper cells (ThP), primary T-helper cells (Th0), and polarized T cells (Th1, Th2)). Heat maps represent log10 intensity values. In the color scheme, saturated red indicates three-fold up-regulation, saturated green indicates three-fold down-regulation, and black indicates unchanged expression.

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