Table 2 Selected genes that were differentially expressed in endocardial vegetations

hla

SACOL1173

22.9

ns

17.5

ns

alpha-hemolysin precursor

hld

SACOL2022

38.5

ns

37.8

ns

delta-hemolysin

hlgA

SACOL2419

18.5

5.4

6.3

2.1

gamma-hemolysin, component A

hlgB

SACOL2421

11.8

2.7

ns

ns

gamma hemolysin, component B

hlgC

SACOL2422

16.5

2.4

ns

ns

gamma hemolysin, component C

lukF

SACOL2004

11.1

18.7

4.9

8.1

leukocidin F subunit

lukS

SACOL2006

11.9

14.7

6.4

8.0

leukocidin S subunit

nuc

SACOL0860

ns

ns

2.9

7.8

thermonuclease

seb

SACOL0907

8.0

ns

4.1

ns

staphylococcal enterotoxin B

splB

SACOL1868

10.7

5.7

ns.

ns

serine protease

splC

SACOL1867

ns

ns

3.4

2.5

serine protease

splD

SACOL1866

ns

ns

3.8

2.9

serine protease

splE

SACOL1865

28.4

11.6

16.9

7.5

serine protease

aur

SACOL2659

3.3

2.4

2.2

ns

zinc metalloproteinase aureolysin

clpB

SACOL0979

ns

ns

4.4

8.1

ATP-dependent protease

ssaA

SACOL2581

5.7

13.1

2.6

5.1

staphylococcal secretory antigen; staphyloxanthin biosynthesis protein

sodA

SACOL1610

-5.7

-4.5

-5.7

-4.5

superoxide dismutase

cap5A

SACOL0136

8.5

2.8

8.8

3.0

capsular polysaccharide biosynthesis protein

cap5B

SACOL0137

7.3

2.6

7.4

2.6

capsular polysaccharide biosynthesis protein

cap5D

SACOL0139

6.3

2.2

7.4

3.8

capsular polysaccharide biosynthesis protein

cap5E

SACOL0140

13.4

10.2

9.1

6.8

capsular polysaccharide biosynthesis protein

cap5F

SACOL0141

5.3

3.6

ns

ns

capsular polysaccharide biosynthesis protein

cap5G

SACOL0142

4.3

2.5

6.6

4.0

capsular polysaccharide biosynthesis protein

cap5I

SACOL0144

3.3

ns

4.1

2.3

capsular polysaccharide biosynthesis protein

cap5J

SACOL0145

ns

ns

2.2

2.4

capsular polysaccharide biosynthesis protein

dltA

SACOL0935

-8.5

-2.9

-6.2

-2.1

D-alanine-ligase subunit 1

dltB

SACOL0936

-10.8

-3.4

-9.5

-2.8

D-alanyl-lipoteichoic acid biosynthesis protein

dltC

SACOL0937

-4.9

ns

-4.9

ns

D-alanine-ligase subunit 2

dltD

SACOL0938

-13.5

-3.5

-7.4

-2.0

D-alanine transfer protein

clfA

SACOL0856

5.8

ns

5.6

ns

clumping factor A

clfB

SACOL2652

ns

ns

ns

3.1

clumping factor B

fnbA

SACOL2511

3.4

2.7

ns

ns

fibronectin-binding protein A

sasF

SACOL2668

12.2

10.5

14.4

12.9

LPXTG cell wall surface anchor family protein

sdrC

SACOL0519

12.3

8.7

8.6

6.5

Ser-Asp repeat protein

pls

SACOL0050

-2.3

-3.3

ns

-4.3

surface protein

sasA

SACOL2676

ns

-9.8

2.2

-4.2

LPXTG cell wall surface anchor family protein

spa

SACOL0095

-6.3

-4.9

-5.7

-4.5

immunoglobulin G-binding protein A precursor

sbnA

SACOL0112

ns

ns

48.9

22.2

siderophore biosynthesis protein

sbnB

SACOL0101

ns

ns

25.9

19.7

siderophore biosynthesis protein

sbnD

SACOL0103

ns

ns

18.4

17.1

siderophore biosynthesis protein

sbnE

SACOL0104

ns

ns

23.0

18.4

siderophore biosynthesis protein

sbnG

SACOL0106

ns

ns

21.6

25.2

siderophore biosynthesis protein

sbnH

SACOL0107

ns

ns

15.4

16.8

siderophore biosynthesis protein

sbnI

SACOL0108

ns

ns

23.5

30.0

siderophore biosynthesis protein

sirR

SACOL0691

2.3

ns

ns

ns

iron-dependent repressor

sirB

SACOL0098

2.9

ns

ns

ns

iron compound ABC transporter, permease

SACOL2167

ns

ns

2.9

ns

iron complex transport substrate-binding protein

SACOL2169

4.4

ns

4.2

ns

aerobactin biosynthesis protein

SACOL2170

ns

ns

2.6

ns

major facilitator transporter

isdD

SACOL1142

3.1

ns

2.3

ns

Heme ABC transporter

dapF

SACOL2479

18.2

18.9

15.2

15.6

diaminopimelate epimerase family protein

SACOL2478

9.2

9.4

7.8

8.3

conserved hypothetical protein

SACOL2477

17.6

12.8

20.9

15.1

conserved hypothetical protein

opp1A

SACOL2476

18.1

11.1

10.8

13.9

peptide ABC transporter

opp1B

SACOL2475

4.3

3.4

11.2

9.0

peptide ABC transporter, permease

opp1C

SACOL2474

15.9

12.9

30.4

24.0

peptide ABC transporter, permease

opp1D

SACOL2473

ns

ns

8.0

7.3

peptide ABC transporter ATP-binding protein

opp1F

SACOL2472

ns

ns

21.5

20.9

peptide ABC transporter ATP-binding protein

norD

SACOL2471

17.8

12.3

27.0

18.5

transporter, putative

epiG

SACOL1871

2.4

ns

2.6

ns

lantibiotic ABC transporter protein

epiE

SACOL1872

4.2

ns

4.4

ns

lantibiotic ABC transporter protein

epiF

SACOL1873

5.5

ns

5.7

ns

lantibiotic ABC transporter protein

malE

SACOL0193

ns

ns

3.1

2.5

maltose ABC transporter, maltose-binding

malF

SACOL0194

7.4

3.9

6.0

3.5

maltose ABC transporter, permease protein

malK

SACOL0192

14.7

14.7

6.2

6.8

maltose ABC transporter, ATP-binding protein

opuD

SACOL2176

2.0

2.4

ns

ns

osmoprotectant transporter, BCCT family

tet38

SACOL0122

21.2

12.2

13.1

8.9

tetracycline-resistance protein, putative

ulaA

SACOL0400

12.9

5.6

7.3

3.2

PTS system ascorbate-specific transporter

uhpT

SACOL0200

125

29

78.1

18.1

sugar phosphate antiporter

kdpA

SACOL2068

ns

ns

8.5

15.0

potassium-transporting ATPase, C subunit

kdpB

SACOL2067

ns

ns

9.0

13.3

potassium-transporting P-type ATPase, B unit

norB

SACOL1475

25.1

27.5

16.1

17.3

drug transporter, quinolone-resistance protein

SACOL1476

24.8

22.4

18.7

18.6

transmembrane amino acid transporter

ilvA

SACOL1477

34.0

25.0

28.7

22.7

threonine dehydratase

ald

SACOL1478

42.3

24.0

31.2

17.6

alanine dehydrogenase

mntH

SACOL1114

-9.5

-6.3

-9.4

-6.3

Mn2+/Fe2+ transporter

SACOL1115

-3.9

-4.0

-4.3

-4.4

hypothetical protein

mntC

SACOL0688

3.7

-5.8

3.5

-6.3

ABC transporter substrate-binding protein

mntB

SACOL0689

4.1

-5.7

4.5

-4.7

ABC transporter permease

mntA

SACOL0690

8.5

-2.7

5.6

-4.4

ABC transporter ATP-binding protein

SACOL0157

-11.4

-12.0

-12.9

-12.8

conserved hypothetical protein

SACOL0158

-6.8

-15.2

-6.1

-13.4

ABC transporter, ATP-binding protein

SACOL0159

-6.9

-8.2

-5.0

-6.1

ABC transporter, permease protein

SACOL0160

-4.9

-7.1

-5.5

-7.9

conserved hypothetical protein

adhE

SACOL0135

22.9

22.3

30.9

31.1

alcohol dehydrogenase, iron-containing

ald

SACOL1478

42.3

24.0

31.2

17.6

alanine dehydrogenase

arcB1

SACOL1181

ns

ns

2.2

2.5

ornithine carbamoyltransferase

arcC

SACOL1182

21.8

15.3

12.9

9.9

carbamate kinase

arcD

SACOL1183

8.7

5.9

6.8

4.8

arginine/ornithine antiporter

arcA

SACOL2657

12.4

12.2

8.4

8.5

arginine deiminase

arcB2

SACOL2656

6.4

7.6

4.6

5.3

ornithine carbamoyltransferase

arcD

SACOL2655

30.1

43.5

27.6

43.1

arginine/ornithine antiporter

argG

SACOL0963

ns

ns

3.4

6.4

argininosuccinate synthase

argH

SACOL0964

ns

ns

5.4

13.3

argininosuccinate lyase

deoB

SACOL0124

4.0

2.2

4.4

2.3

phosphopentomutase

deoD

SACOL0121

7.1

7.8

8.9

10.0

purine nucleoside phosphorylase

gltA

SACOL1742

6.9

-6.7

4.8

-9.4

citrate synthase

gntK

SACOL2515

6.9

4.9

ns

ns

gluconokinase

ilvA

SACOL1477

34.0

25.0

28.7

22.7

threonine dehydratase

nirB

SACOL2398

21.8

19.6

12.8

11.9

nitrite reductase [NAD(P)H], large subunit

nirD

SACOL2397

8.1

6.1

4.7

3.9

nitrite reductase [NAD(P)H], small subunit

pflA

SACOL0205

94.7

125.7

116.5

157.6

pyruvate formate-lyase-activating enzyme

pflB

SACOL0204

44.7

46.9

59.9

65.6

formate acetyltransferase

rbsK

SACOL0253

6.9

2.5

4.9

ns.

ribokinase

SACOL2396

19.0

14.3

7.4

6.1

uroporphyrin-III C-methyl transferase

SACOL1476

24.8

22.4

18.7

18.6

amino acid permease

agrA

SACOL2026

ns

ns

4.8

ns

accessory gene regulator protein A

agrC

SACOL2025

-2.6

-3.3

4.5

-2.2

accessory gene regulator protein C

agrD

SACOL2024

2.3

-4.0

5.2

ns

accessory gene regulator protein D

gntR

SACOL2516

5.0

4.1

ns

ns

gluconate operon transcriptional repressor

purR

SACOL0539

ns

2.3

ns

ns

pur operon repressor

rsbV

SACOL2056

ns

3.6

ns

3.7

anti-anti-sigma factor RsbV

rsbW

SACOL2055

ns

2.7

ns

3.0

anti-sigma B factor

sarA

SACOL0672

ns

2.5

ns

2.1

transcriptional regulator

sarS

SACOL0096

-14.7

-7.2

-8.7

-4.2

transcriptional regulator

sigB

SACOL2054

ns

ns

ns

2.1

alternative sigma factor

fur

SACOL1541

ns

ns

-2.1

-3.1

transcriptional regulator, Fur family

araC

SACOL2378

-3.6

-2.7

ns

ns

transcriptional regulator, AraC family

tetR

SACOL2374

ns

ns

-2.0

-2.4

transcriptional regulator, TetR family

vraR

SACOL1942

-4.8

-3.2

-3.7

-2.5

DNA-binding response regulator

vraS

SACOL1943

-4.3

-2.8

-3.3

-2.2

sensor histidine kinase