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Figure 3 | Genome Medicine

Figure 3

From: Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis

Figure 3

Protein-protein interaction networks of CFTR-related genes. A total of 419 genes were retrieved from the study of Ramachandran et al. of which 123 could be mapped to the STRING database version 9.1. Only PPI interaction for homo sapiens were considered and a confidence score >0.4 was requested. Among them we considered those genes linked to the 15 composite FFL that were constructed. This revealed 80 genes and a total of 135 PPIs to be in common. Subsequently, for nine disease-specific composite FFLs 66 genes and 97 PPIs were observed.

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Genome Medicine

ISSN: 1756-994X

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