Figure 4

PDXs as substitutes for patient tumours: 450 K versus MeDIP-seq. (a) The absolute difference in β-value between the two OS patient tumours is calculated at each probe. The absolute difference between each PDX and the patient tumour from the other tumour set is then assessed, and a ΔΔβ for those two differences is calculated and plotted as in Figure 3. A result close to zero indicates concordance between the two measurements at a given CpG site. (b) Similarly to the process described above with the 450 K array, the number of DMRs between the two patient tumours that can be recapitulated between a PDX and the patient tumour are shown, for both hyper- and hypo-DMRs.