Overview of the SCAN-B infrastructure. Shown are the SCAN-B clinical (green boxes), laboratory (blue), and computational and analytical (orange) components. Solid black arrows indicate flow of material, and dashed black lines indicate flow of information. Enrollment and sampling of patients at time of preoperative (neoadjuvant) biopsy is not shown. ds, double-stranded; INCA, Swedish national breast cancer registry; TMA, tissue microarray.