Table 2 Somatic mutations affecting TET genes in cancer

TET1

Rare in endometrioid carcinoma^a, colorectal carcinomas [105,137], lung [106,138,139] and bladder cancer [140]

Rare in AML [141] and CLL [142]

TET2

Rare in endometrioid carcinoma^a, colorectal carcinomas [105,137], melanoma and lung cancer [106,138,139]

Frequent in various cancers (see Table 3)

TET3

Rare in endometrioid carcinoma and colorectal carcinomas [105,137]

Rare in CLL [142], PTCL [90] and T-ALL [143]

Methyltransferases

DNMT1

Rare in endometrioid carcinoma^a, colorectal carcinomas [105,137], and lung cancer [106,138,139]

Rare in AML [141]

DNMT3A

Rare in endometrioid carcinoma^a, colorectal carcinomas [105,137], lung cancer [106,138,139] and 2% in non-small cell lung cancer [144]

AML [128], MDS [145] and T-cell lymphomas [90,91]

Deaminase and glycosylase

AID

Rare in glioblastoma and medulloblastoma [146], endometrioid carcinoma^a, colon cancer [105,137] and lung cancer [106,138,139]

T-ALL [147]

TDG

Rare in endometrioid carcinoma^a, rare in glioblastoma^a, colon cancer [104,136], lung [106,138,139] and thyroid cancer [148]

Not reported

Histone crosstalk regulators

OGT

Rare in endometrioid carcinoma^a, colorectal carcinomas [105,137], lung cancer [106,138,139] and breast cancer [115,149]

DLBCL [150] and CLL [142]

IDAX

Rare in breast cancer^a, glioblastoma^a, endometrioid carcinoma^a, kidney^a, colon cancer [105,137], lung cancer [106,138,139] and 1.2% in mouth and pharynx carcinoma [117]

Not reported

5-mC and 5-hmC readers

MBD1

Rare in endometrioid carcinoma^a, colorectal carcinomas [105,137], lung cancer [106,138,139], breast cancer [149] and melanoma [109]

Rare in ALL [151]

MBD4

Rare in endometrioid carcinoma^a, colorectal carcinomas [105,137], lung cancer [106,138,139], breast cancer [115] and melanoma [109]

Rare in AML [141]

UHRF1

Rare in endometrioid carcinoma^a, colorectal carcinomas [105,137] and lung cancer [106,138,139]

Rare in B-ALL [152]

Metabolic enzymes

IDH1

Rare in paragangliomas [153], frequent in chondrosarcomas [154], thyroid [155,156], prostate [157] and central nervous system cancers [102,158,159]

Frequent in AML [88], MDS [160], DLBCL [161] and B-ALL [162]

IDH2

Rare in endometrioid carcinoma^a and colorectal carcinomas [105,137], frequent in chondrosarcomas [154] and central nervous system cancers [102,158,159]

Frequent in AML [88], MDS [160] and AITL [89]

FH

Renal cell carcinoma [163] and paragangliomas [104]

Not reported

SDH

Renal cell carcinoma [164] and paragangliomas [104]

Not reported