Schematic summary of genomic associations to UC DMR methylation patterns. (A) Mean tumor subgroup methylation levels with respect to DMR methylation patterns. Methylation levels are indicated in blue (low) to red (high). (B) Pattern 1 to 3 DMRs display differential binding of regulatory factors in ENCODE cell lines. (C) A model of modes of RF binding at pattern 2 and pattern 3 DMRs, indicating differential regulatory function or modular organization underlying differential methylation. (D) Mean pattern 1 to 3 methylation levels in tumors belonging to the different HOXA methylation groups. (E) Lund gene expression subtype distribution across the HOXA methylation groups.