Inferred mutation signatures and their contributions to somatic mutations in bladder cancers, UTUCs, and HCCs. (A) EMu discerned three mutation signatures. The height of each bar (the y axis) represents the proportion of mutations in the inferred signature that fall into a particular trinucleotide mutation class, adjusted for the frequency of the trinucleotide in the exome. (B) The contributions of each mutation signature (that is, inferred mutational process) to the somatic mutations in each tumor in Table 1. BGI-Bladder: tumors reported in reference 36.