Fig. 5

Kinome profiling identifies MSCs as a distinct cell population. a MSCs can be clustered by their unique kinome profile, which distinguishes them from primary fibroblasts and established fibroblast cell lines. Visual representation based on the Pearson correlation coefficient of log₂ fold changes in growth and cell proliferation. Kinome data from primary fibroblasts (pHF1, pHF2) and fibroblast cell lines (HFF, HS68) and primary MSCs. b Bi-dimensional clustering of kinome-viability phenotypes from all screened cells reveals a set of 35 kinases with a differential effect on cell viability between MSCs and fibroblasts. c All kinases with a differential phenotype were analyzed by STRING (v.9.0) to create a curated interaction network [34]. Out of the 35 identified kinases, 12 form an interaction network which is enriched in B-cell-receptor signaling components