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Table 3 Population genetic statistics of the OCT1 gene for the different world regions

From: Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

World region π (×10−4)   θ (×10−4)   Tajima’s D
All LOF Non-LOF πLOF / πnon-LOF   All LOF Non-LOF   All LOF Non-LOF
Sub-Saharan Africa 4.91 0.85 4.06 0.21   5.19 1.73 3.46   −0.096 −0.601 0.271
North Africa and Middle East 5.73 2.59 3.15 0.82   9.45 5.67 3.78   −0.869 −1.040 −0.280
Europe 7.93 3.06 4.87 0.63   8.52 4.65 3.87   −0.140 −0.568 0.400
Central Asia 7.60 2.36 5.24 0.45   11.73 5.42 6.32   −0.803 −1.042 −0.330
East Asia and Oceania 5.48 0.16 5.32 0.03   7.99 4.79 3.20   −0.621 −1.638* 0.976
America 3.63 2.76 0.87 3.18   4.25 1.06 3.18   −0.268 1.675 −1.204
  1. LOF, loss-of-function. Included are all variants causing a more than 50 % reduction in OCT1 activity for at least one substrate tested, that is, Ser14Phe, Ser29Leu, Arg61Cys, Cys88Arg, Ser189Leu, Arg206Cys, Thr245Met, Glu284Lys, Gly401Ser, Met420del, Ile449Thr, and Gly465Arg; non-LOF, non-loss-of-function. Included are all variants that did not affect or caused an increase in OCT1 activity, that is, Pro117Leu, Phe160Leu, Pro341Leu, Arg342His, Met408Val, Gly414Ala, and Arg488Met
  2. *P <0.01