Table 1 Characteristics of the healthy volunteers (controls) and patients with INSR mutations or LD

Gender

15 F, 12 M

6 F, 1 M

12 F, 2 M

Age (years)

39 ± 14

27 ± 11

36 ± 9

0.14

BMI (kg/m²)

24.6 ± 2.6

23.2 ± 3.6

24.1 ± 2.4

0.50

Fat mass (kg)

20.9 ± 8.5

22.6 ± 10.0

10.2 ± 5.0

<0.01

Lean mass (kg)

47.3 ± 10.8

34.2 ± 3.8

53.9 ± 10.7

<0.01

Glucose (mmol/l)

4.5 ± 0.5

4.7 ± 0.8

6.4 ± 2.7

<0.01

Insulin (pmol/l)

27 ± 20

419 ± 269

116 ± 65

<0.01

Adiponectin (mg/l)

6.4 ± 3.2

10.5 ± 7.9

2.9 ± 3.3

<0.01

Leptin (μg/l)

16.9 ± 22.1

16.1 ± 8.1

4.2 ± 3.0

0.24

Triglyceride (mmol/l)

0.9 ± 0.4

1.0 ± 0.3

2.9 ± 2.3

<0.01

HDL-cholesterol (mmol/l)

1.5 ± 0.4

1.8 ± 0.4

0.9 ± 0.5

<0.01