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Table 1 Characteristics of the healthy volunteers (controls) and patients with INSR mutations or LD

From: Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes

  Controls Insulin receptoropathies Lipodystrophy P value
Gender 15 F, 12 M 6 F, 1 M 12 F, 2 M  
Age (years) 39 ± 14 27 ± 11 36 ± 9 0.14
BMI (kg/m2) 24.6 ± 2.6 23.2 ± 3.6 24.1 ± 2.4 0.50
Fat mass (kg) 20.9 ± 8.5 22.6 ± 10.0 10.2 ± 5.0 <0.01
Lean mass (kg) 47.3 ± 10.8 34.2 ± 3.8 53.9 ± 10.7 <0.01
Glucose (mmol/l) 4.5 ± 0.5 4.7 ± 0.8 6.4 ± 2.7 <0.01
Insulin (pmol/l) 27 ± 20 419 ± 269 116 ± 65 <0.01
Adiponectin (mg/l) 6.4 ± 3.2 10.5 ± 7.9 2.9 ± 3.3 <0.01
Leptin (μg/l) 16.9 ± 22.1 16.1 ± 8.1 4.2 ± 3.0 0.24
Triglyceride (mmol/l) 0.9 ± 0.4 1.0 ± 0.3 2.9 ± 2.3 <0.01
HDL-cholesterol (mmol/l) 1.5 ± 0.4 1.8 ± 0.4 0.9 ± 0.5 <0.01
  1. Data presented are mean ± standard deviation. BMI body mass index, F female, HDL high-density lipoprotein, M male