Fig. 11

Two patterns are found through the comparing between AD (top) and ID (bottom) groups in time-sequence analysis of network cohesiveness. The two patterns on the left (Patterns 1 and 2) differ between the AD and ID patients. In Pattern 1, there is a set of modules that increases in cohesiveness in the 6- to 12-month time period only in the AD patients. Note in Pattern 2 the increase in module cohesiveness in the AD patients over the baseline to 4-month time period. This properties of this same set of modules remains unchanged in the ID group. These findings are consistent with clinical data from the TREAT trial demonstrating the importance of the first 4 to 6 months of therapy in determining longer-term response. The final pattern (Pattern 3) shares similar evolutionary features between the two groups