Fig. 7

Evolutionary events detected from strategy-based analysis when the threshold is set to 0.16. The 50 gene clusters are aligned vertically at each timestamp. a The evolutionary events detected in non-responders where the functional module detected at stages 1, 2a, and 3 interact with each other; b The evolutionary events detected in responders where the functional module detected at stages 1, 2b, and 3 interact with each other. c Pie graphs of evolutionary event calculation of both non-responders and responders, where the percent of five evolutionary events at a certain time gap are shown. Note again the paucity of ‘continue’ events as well as the greater number of ‘dissolve’ events in the responders