Fig. 8

Evolutionary events detected from strategy-based analysis when threshold is set to 0.2. The 50 gene clusters are aligned vertically at each timestamp. a The evolutionary events detected in non-responders where the functional module detected at stages 1, 2a, and 3 interact with each other; b The evolutionary events detected in responders where the functional module detected at stages 1, 2b, and 3 interact with each other. c Pie graphs of evolutionary event calculation for both non-responders and responders, where the percent of five evolutionary events at a certain time gap are shown. Note that, even in this more stringent analysis, non-responders have more merge, split, and continue events than responders during the first 4 months of therapy (that is, the time period between stage 1 (baseline) and stage 2a or 2b)