Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5

Table 3 Replication data using SNP rs12598453:C > G as a representative of the three SNPs referred to in the text

Cohort	Number of individuals	Number of controls, cases	AF in cases, controls	P value, case-control allelic chi-squared test	BMI averages by genotype: CC, CG, GG
Sequenced men	284	161, 123	0.491, 0.646	0.00021	25.2, 26.03, 28.13
Male GOYA	1,450	785, 665	0.496, 0.547	0.0054	26.51, 26.89, 27.39
GOYA men, younger than 25 years	1,381	749, 632	0.493, 0.551	0.0027	26.45, 26.85, 27.47
Female GOYA	3,908	1948, 1960	0.507, 0.529	0.056	30.00, 30.21, 30.46
GOYA women, younger than 25 years	562	255, 307	0.465, 0.560	0.0014	29.79, 30.67, 32.5
All combined	5,401	2762, 2639	0.503, 0.534	0.0012	29.04, 29.24, 29.63
All combined, younger than 25 years	1,984	1032, 952	0.486, 0.556	0.000011	27.35, 27.85, 28.89

ISSN: 1756-994X