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Fig. 1 | Genome Medicine

Fig. 1

From: Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

Fig. 1

Genome-wide distribution and characteristics of differentially methylated regions identified in the superior temporal gyrus of patients with Alzheimer’s disease (AD). a Manhattan plot showing -log10 P-values from the sliding-window analysis of autosomal CpGs in AD cases versus controls. b Comparison of population level mean β-values for hypomethylated (blue, n = 1,260) and hypermethylated (red, n = 3,395) CpGs, and background CpGs (black; all autosomal CpGs screened, n = 461,272). c Distribution of per CpG mean β-value changes associated with AD status (>0, red; <0, blue) estimated by multiple regression, after regressing out effects of age, gender, race, and neuronal/glial cell proportions. Only data for CpGs within DMRs that were independently significant by linear regression (P < 0.05; n = 2,220) are plotted

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