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Fig. 6 | Genome Medicine

Fig. 6

From: Identification of key regulators of pancreatic cancer progression through multidimensional systems-level analysis

Fig. 6

Functional gene networks of genes under multiple regulatory controls (GMCs). a Global network of interacting molecules obtained from multidimensional pancreatic ductal adenocarcinoma (PDAC) meta-signatures. b Comprehensive GMC (CGMC) network containing GMCs and their first neighbors extracted from global multidimensional PDAC network. The key regulatory hubs in the CGMC network are highlighted in yellow. Subnetworks (I, II, III, IV and V) of the top five key regulators (E2F3, NUAK1, ACTN1, RASA1 and SKI) were identified from topological analysis of the CGMC network. The network genes are represented as circles and miRNAs as hexagons. Upregulated molecules are shown in shades of red while downregulated molecules shown in shades of green

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Genome Medicine

ISSN: 1756-994X

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