Fig. 6

ROC curve analyses for the SYFPEITHI benchmark dataset. Binding to the restriction element was predicted for all unique 8–11mer peptides within the source proteins from the SYFPEITHI benchmark using the allmer method. Binding values were reported as binding affinity and percentile rank values as described in the text. ROC curves were calculated for each prediction value taking ligands as positives and all other peptides as negatives. The inset plot shows the information divergence value (ID) as a function of the percentage of peptides selected. The ID was calculated from the proportion of peptides with predicted restriction to each of the MHC molecules in the benchmark compared to the proportion expected by sampling at random