Fig. 2

Deep human saliva proteomes of eight healthy donors. a Ovals represent the number of saliva proteins shared by the respective number of donors. The outer oval contains all proteins that were detected in at least one donor, whereas the inner oval contains all proteins found in each sample—the core proteome. The numbers on the right indicate the numbers of proteins exactly found in one donor, in two donors, and so on. b Gene names of the 15 most abundant saliva proteins, their coefficients of variation (CVs) across eight donors at waking (w) and after breakfast and tooth brushing (p), as well as their abundances in percentage of the total proteome and the cumulative protein abundances (cum. amount). The proteins in blue are digestive proteins, the proteins in green are part of immune defense, and the proteins in red are of epithelial origin. c Dynamic range plot of the saliva proteome with some key proteins in saliva highlighted in red. Significantly enriched GO terms or Uniprot keywords in specific abundance regions as determined by 1D annotation are listed. d Scatter plot of the LFQ intensities of the saliva proteome and the plasma proteome