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Fig. 7 | Genome Medicine

Fig. 7

From: Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet

Fig. 7

Fecal microbial compositions are associated with host body phenotypes and disease indications. a Isometric multidimensional scaling (MDS) of Euclidean distances between clr-transformed OTU compositions, with within-subject variances extracted. The first two MDS components are shown, with Control vs. STAT and NC vs. HFD (point color, shape) explicitly modeled in this approach. This was done by evaluating between-subject variances within each respective group and subtracting from the full dataset. b Within-subject response-selected OTUs are shown as biplots. For each phenotype of interest (NAFLD, BMC, or Weight), the relevant two-component (out of seven possible latent components) subspaces from the sPLS model are shown. Taxa are filtered for statistical significance (α = 10–2) and key taxa are highlighted for biological significance. “Response Level” indicates the centered and scaled within-subject variances of the relevant measurement

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Genome Medicine

ISSN: 1756-994X

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