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Fig. 3 | Genome Medicine

Fig. 3

From: An adaptive association test for microbiome data

Fig. 3

Type I error and power comparison for scenario 2 with a binary outcome. A selected phylogenetic cluster (0.35 %) of the OTUs was associated with the outcome. X and Z are independent (a) or correlated (b). K u, K w, and K 5 represent MiRKAT results from the unweighted UniFrac kernel, weighted UniFrac kernel, and generalized UniFrac kernels with α=0.5, respectively. K opt represents the simulation results for optimal MiRKAT considering the Bray–Curtis kernel, unweighted UniFrac kernel, weighted UniFrac kernel, and generalized UniFrac kernel. MiSPUu(2), MiSPUu(), and aMiSPUu represent the MiSPUu test with γ=2, and aMiSPUu summarizing γ=2,3,…,8,, respectively. aMiSPUw and aMiSPU represent the test summarizing γ=2,3,…,8, with weighted generalized taxon proportion and combining aMiSPUu and aMiSPUw, respectively. Results were presented at n=100

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