Statistical inference of a convergent antibody repertoire response to influenza vaccine

Table 1 Top ten TIV-responding heavy chain V genes

Gene name	Lit Ab Freq.	Combined	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5
IGHV3-23	0.10345	1.08E-14	1.54E-05	4.55E-05	0.00529688	0.00010769	0.00015385
IGHV1-69	0.23707	5.04E-14	0.00043284	0.00290909	0.00028125	6.15E-05	1.54E-05
IGHV3-30	0.03879	7.19E-13	0.00153731	0.00154546	0.00025	0.00069231	1.54E-05
IGHV3-7	0.04310	1.15E-12	0.00020896	0.00792424	1.54E-05	0.00010769	0.00389231
IGHV4-61	0.00215	1.16E-12	0.00132836	7.58E-05	0.02834375	3.08E-05	0.00012308
IGHV4-31	0.00431	1.78E-12	0.00110448	0.00424242	0.0015625	3.08E-05	7.69E-05
IGHV3-48	0.01940	2.36E-12	0.00032836	0.00040909	0.0001875	0.00096923	0.00096923
IGHV4-59	0.15302	2.77E-12	0.00011940	0.00013636	0.01929688	4.62E-05	0.00195385
IGHV3-11	0.00431	3.14E-12	0.00037313	0.00074242	0.00025	0.00015385	0.00306154
IGHV3-30-3	0	4.71E-11	0.00219403	0.01130303	0.00153125	0.00115385	1.54E-05

Lists the top ten scoring IGHV genes in the FPCA-based test for the B cell data. “Lit. Ab Freq.” lists the frequency for each of the V genes in the literature-curated dataset. “Combined” lists the p values for each of the V genes after using Fisher’s method to combine the p values from the FPCA-based test across all the patients. Patient 1–5 lists the p values for each of the individual patients from the FPCA-based test. Genes are sorted by combined p value

ISSN: 1756-994X