Fig. 3

Genome-wide binding profiles of LXRs and PPARG. a Normalized sequencing read depth rank correlation (top left) at all ChIP-seq binding sites identified across replicate LXRB (light blue), PPARG (gold), and LXRA (dark blue) ChIP-seq experiments after 2 and 48 h of drug treatment. The top panel shows 2-h drug treatment replicate ChIP-seq comparisons while the bottom panel displays 48-h comparisons. b Enriched canonical LXR and PPARG motif identified in corresponding ChIP-seq data. c Venn diagram comparisons of binding events between 2 and 48 h of drug treatment. Overlapping sites are shown in gray, while sites identified at only 2 or 48 h are shown at the left and right, respectively. The number of sites in each category is presented for each category. d The percentage of all LXRB and PPARG sites that were identified at 2 h only (light green), 48 h only (dark green), and common to both time points (common, gray). e Read depth ratios (x-axis) at all LXRB binding sites. Negative values highlight stronger enrichment after 48 h of GW3965 treatment while positive values denote stronger occupancy after 2 h. f Read depth ratios (x-axis) at all PPARG binding sites. Negative values highlight stronger enrichment after 48 h of rosiglitazone treatment while positive values denote stronger read enrichment after 2 h