Fig. 1
From: Cancer network activity associated with therapeutic response and synergism
Strategy analysis. The basal gene expression of hundreds of cancer cell lines is integrated into the interactome network and a CNA score is then assigned to each cell line by computing a weighted adjacency matrix. Next, CNA measures are evaluated for their correlations with types of drugs or therapies, network topology, biological processes and signaling pathways, cancer drivers, and drug synergies